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. 2014 Apr 10;2014:902735. doi: 10.1155/2014/902735

Figure 3.

Figure 3

NPPB-sensitive Isc. The NPPB-sensitive Isc was measured as the difference of Isc just before and 30 min after addition of 100 μM NPPB to the apical solution. n = 5 for DMSO, n = 6 for quercetin, and n = 7 for myricetin without forskolin ((−) FK). n = 6 for DMSO, n = 5 for quercetin, and n = 8 for myricetin with forskolin ((+) FK). Under basal conditions ((−) FK), the values of quercetin-stimulated Isc (∗) and myricetin-stimulated NPPB-sensitive Isc (∗∗) were significantly larger than the NPPB-sensitive Isc with DMSO alone (solvent control; P < 0.001). The value of Isc with DMSO alone under forskolin-stimulated conditions (DMSO marked with § in (+) FK) was significantly larger than that with DMSO alone under basal conditions (DMSO in (−) FK; P < 0.001). Under forskolin-stimulated conditions ((+) FK), the value of quercetin-stimulated Isc (Quercetin in (+) FK marked with #) was significantly smaller than that with DMSO alone (DMSO in (+) FK; P < 0.001). On the one hand, under forskolin-stimulated conditions ((+) FK), the value of myricetin-stimulated Isc (##) was significantly larger than that with DMSO alone (DMSO in (+) FK; P < 0.001). The value of quercetin-stimulated Isc was identical irrespective of forskolin stimulation (Quercetin in (−) FK versus Quercetin in (+) FK; NS, no significant difference), while the value of myricetin-stimulated Isc under forskolin-stimulated conditions (Myricetin in (+) FK) was significantly larger than that under basal condition (Myricetin in (−) FK; P < 0.001).