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. 2014 Apr 22;8:21. doi: 10.3389/fnana.2014.00021

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Copyright © 2014 Le Pichon and Chesler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPV1 Reporter mice reveal the anatomy of neurons that expressed TRPV1 throughout their lineage. (A) Skin section from TRPV1-Cre × YFP reporter strain showing primary afferent arborizations in the various epidermal layers. (B) DRG section from adult TRPV1-PLAP-nlacZ mouse, showing minimal overlap between β-Gal reaction product (green) and IB4 (red). (C) DRG section from adult TRPV1-Cre × LacZ reporter strain. Anti-LacZ (green) shows significantly more overlap with IB4 (red) since the entire TRPV1 lineage is marked. Image courtesy of Danial Cavanaugh and Allan Basbaum, Department of Anatomy UCSF.