Table 1.
Marker | Sensory cell type |
---|---|
Parvalbumin | Proprioceptors and Aβ fibers |
CGRP | Peptidergic C fibers, sub-population of Aδ fibers |
Substance P | Peptidergic C fibers |
NF200 | Myelinated Aδ fibers, Aβ fibers, and proprioceptors |
IB4 | Non-peptidergic C fibers |
Trpv1 | Small diameter C fibers (heat and pain) |
Trpm8 | Small diameter C fibers (cold and pain) |
MrgprD | Small diameter C fibers (noxious mechanical, pain) |
MrgprA3 | Small diameter C fibers (itch) |
MrgprB4 | Small diameter C fibers (innocuous mechanical) |
VGlut3 | Non-peptidergic C fibers (innocuous mechanical, cooling) |
TH | Non-peptidergic C fibers (innocuous mechanical, cooling) |
TrkB | Aδ fibers (innocuous mechanical, cooling) |
Npy2r | Aβ fibers (innocuous mechanical) |
Chondrolectin | Aβ fibers (innocuous mechanical) |
DOR | Sub-populations of non-peptidergic C fibers and myelinated NF200-positive fibers |
Abbreviations: CGRP, calcitonin gene-related peptide; NF200, neurofilament heavy chain 200; IB4, isolectin B4; Trpv1, transient receptor potential cation channel subfamily V member 1; Trpm8, transient receptor potential cation channel subfamily M member 8; MrgprD, Mas-related G-protein-coupled receptor D; MrgprA3, Mas-related G-protein-coupled receptor A3; MrgprB4, Mas-related G-protein-coupled receptor B4; VGluT3, vesicular glutamate transporter type 3; TH, tyrosine hydroxylase; TrkB, tyrosine receptor kinase B; Npy2r, neuropeptide Y receptor type 2; DOR, delta opioid receptor.