Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Apr 21;8:60. doi: 10.3389/fnsys.2014.00060

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Frye, Koonce and Walf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) Depicts the mean (+s.e.m.) 3α,5α-THP levels in the midbrain of proestrous rats infused first with control and vehicle (veh, n = 5), 3α,5α-THP (n = 7), PK11195 (n = 12), PK11195+3α,5α-THP (n = 11), or pregnane xenobiotic receptor (PXR) antisense deoxynucleotides (AS-ODNs) and veh (n = 10), PXR AS-ODN +3α,5α-THP (n = 8), PXR AS-ODN+ PK11195 (n = 7), PXR AS-ODN + PK11195+ 3α,5α-THP (n = 8) in Experiment 1. (B) Depicts the mean (+s.e.m.) lordosis quotient of proestrous rats in these conditions. Rats infused with PXR AS-ODN had a mean 1.5 fold lower PXR expression in the midbrain compared to control infusions in Experiment 1 (data not shown). ^*above a line indicates a significant effect of PXR AS-ODNs compared to control infusion (P < 0.05). ^*above a bar indicates a significant effect of PK11195 and PK1195+3α,5α-THP compared to vehicle infusions (P < 0.05).