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. 2014 Apr 21;8:60. doi: 10.3389/fnsys.2014.00060

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Copyright © 2014 Frye, Koonce and Walf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Depicts the mean (±s.e.m.) lordosis quotients of proestrous rats infused with control and vehicle (veh, n = 15), control+FGIN (n = 15), pregnane xenobiotic receptor (PXR) antisense deoxynucleotides (AS-ODNs)+vehicle (n = 8), or PXR AS-ODN+FGIN (n = 13) in Experiment 2. (B) Depicts the mean (±s.e.m.) lordosis quotients of ovariectomized (OVX) estradiol (E2)-primed rats infused with control+veh (n = 8), control+FGIN (n = 7), PXR AS-ODN+veh (n = 7), or PXR AS-ODN+FGIN (n = 6) in Experiment 3. (C) Depicts the mean (±s.e.m.) lordosis quotients of OVX/adrenalectomized (ADX), E2-primed rats infused with control+veh (n = 9), control+FGIN (n = 5), PXR AS-ODN+veh (n = 8), or PXR AS-ODN+FGIN (n = 5) in Experiment 4. ^*above a line indicates a significant effect of PXR AS-ODNs compared to control. (P < 0.05).