Table 1.
Activating and inhibitory KIRs and ligands.
| Activating KIR | Ligand | Detectable by FACS | Reference |
|---|---|---|---|
| 2DS1 | HLA-C2 (weaker than 2DL1) | Yes | (14, 15) |
| 2DS2 | HLA-C1 (weak), HLA-A*11:01 | Yes | (16–18) |
| 2DS3 | Unknown | ? (Retained intracellularly?) | (19) |
| 2DS4 | HLA-C*05:01, A*11:02, C*16:01 | Yes | (20) |
| 2DS5 | Unknown | Yes | (21–23) |
| 3DS1 | Unknown | Yes | (24) |
| Inhibitory KIR | Ligand | Detectable by FACS | |
| 2DL1 | HLA-C2 (N77/K80) | Yes | (8) |
| 2DL2 | HLA-C1 (S77/N80), HLA-C2, HLA-B*46:01 and HLA-B*73:01 (C1 epitope) | Yes | (9, 25) |
| 2DL3 | HLA-C1 (S77/N80), HLA-C2, HLA-B*46:01 and HLA-B*73:01 (C1 epitope) | Yes | (9, 25) |
| 2DL4 | HLA-G (intracellular interaction?) | Yes (not shown in vivo) | (26) |
| 2DL5A/B | Unknown | Yes | (27) |
| 3DL1 | HLA-A (with Bw4 motif), HLA-Bw4 | Yes | (11, 28) |
| 3DL2 | HLA-A3/A11 | Yes | (29, 30) |
| 3DL3 | Unknown | ? (Methylated promoter) | (31) |