Table 1.
Chemotherapeutic compounds targeting the homologous recombination DNA repair pathway.
| Compound | Class | Clinical phase | Combination |
|---|---|---|---|
| Mirin | MRN complex | – | – |
| Adenoviral mutant NBS1 | NBS1 | – | Cisplatin |
| Adenoviral mutant Rad50 | Rad50 | – | Cisplatin |
| Telomelysin | MRN complex | I/II | Monotherapy |
| Resveratrol | MRN complex | – | – |
| Caffeine | PIKK | – | – |
| Wortmannin | PIKK | – | – |
| Quercetin | PI3K | – | – |
| LY294002 | ATM and DNA-PKcs | – | – |
| KU-55933 | ATM | – | – |
| KU-60019 | ATM | – | – |
| CP466722 | ATM | – | – |
| KU59403 | ATM | – | – |
| UCN-01 | Chk1 and Chk2 | I | Monotherapy or topotecan or cisplatin |
| XL-844 | Chk1 and Chk2 | I | Monotherapy or gemcitabine |
| AZD7762 | Chk1 and Chk2 | I | Monotherapy or gemcitabine or irinotecan |
| PF-00477736 | Chk1 | I | Gemcitabine |
| SCH900776 | Chk1 | I/II | Monotherapy or cytarabine or gemcitabine |
| LY2603618 | Chk1 | I/II | Gemcitabine or pemetrexed and cisplatin |
| LY2606368 | Chk1 | I | Monotherapy |
| GDC-0425 | Chk1 | I | Monotherapy or gemcitabine |
| GDC-0575 | Chk1 | I | Monotherapy or gemcitabine |
| SAR-020106 | Chk1 | – | – |
| Advexin | p53 | I/II | Monotherapy and chemotherapy drugs |
| SCH-58500 | p53 | I/II | Monotherapy and chemotherapy drugs |
| AdDelta24-p53 | p53 | – | – |
| SG600-p53 | p53 | – | – |
| OBP-700 | p53 | – | – |
| CP-31398 | Stabilizes p53 | – | – |
| PRIMA-1 | Stabilizes p53 | – | – |
| CDB3 | Stabilizes p53 | – | – |
| Peptide 46 | Stabilizes p53 | – | – |
| SCH529074 | Stabilizes p53 | – | – |
| TDRL-505 | RPA | – | – |
| CheSS19 | RPA | – | – |
| MCI13E | RPA | – | – |
| B02 | Rad51 | – | – |
| A03 | Rad51 and RecA | – | – |
| AI-10 | Rad51 and RecA | – | – |
| RI-1 | Rad51 | – | – |
| RI-2 | Rad51 | – | – |
| IBR2 | Rad51 | – | – |
| 3-Aminobenzamide | PARP1 | – | – |
| Olaparib | PARP1 | I/II/III | Monotherapy |
| Veliparib | PARP1 | I | Topotecan or carboplatin or doxorubicin or irinotecan |
| Rucaparib | PARP1 | I/II | Monotherapy or temozolomide |
| CEP-9722 | PARP1 and PARP2 | I/II | Monotherapy or temozolomide |
| MK-4827 | PARP1 | I | Monotherapy or temozolomide |
| BMN 673 | PARP1 and PARP2 | I/II/III | Monotherapy or temozolomide or irinotecan |