Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Chemotherapeutic compounds targeting the non-homologous end joining DNA repair pathway.
| Compound | Class | Clinical phase | Combination |
|---|---|---|---|
| Wortmannin | DNA-PKcs and other PIKKs | – | – |
| LY294002 | DNA-PKcs | – | – |
| NU7026 | DNA-PKcs | – | – |
| NU7441 | DNA-PKcs | – | – |
| SU11752 | DNA-PKcs | – | – |
| OK-1035 | DNA-PKcs | – | – |
| NK314 | DNA-PKcs and topoisomerase II alpha | I | Monotherapy |
| CC-115 | DNA-PKcs and mTOR | I | Monotherapy |
| L189 | DNA ligase IV | – | – |
| SCR7 | DNA ligase IV | – | – |
