Table 1.
Variable | Group | Baseline | 5 h LPS | p-value |
---|---|---|---|---|
pH |
LPS - TEA - |
7.36 [7.33,7.38] |
7.30 [7.26,7.32] |
|
|
LPS + TEA - |
7.36 [7.34,7.39] |
7.30 [7.28,7.34] € |
€ 0.019 |
|
LPS + TEA + |
7.37 [7.34,7.40] |
7.32 [7.29,7.45] |
|
paCO2 (mmHg) |
LPS - TEA - |
49 [45,51] |
46 [42,50] |
|
|
LPS + TEA - |
45 [37,48] |
30 [27,36] € * |
€ < 0.001 |
|
LPS + TEA + |
47 [45,50] |
37 [30,40] € * |
€ < 0.001 |
paO2 (mm Hg) |
LPS - TEA - |
72 [64,81] |
89 [67,94] € |
€ 0.016 |
|
LPS + TEA - |
79 [73 , 86] |
101 [96 , 105] € * |
€ < 0.001 |
|
LPS + TEA + |
78 [66,83] |
95.5 [85,104] € |
€ < 0.001 |
Hematocrit (%) |
LPS - TEA - |
48 [44,50] |
46 [41,47] € |
€ 0.024 |
|
LPS + TEA - |
47 [46,49] |
36 [34,39] € * |
€ < 0.001 |
|
LPS + TEA + |
49 [46,51] |
36 [35,37] € * |
€ < 0.001 |
Base excess (mM) |
LPS - TEA - |
-0.4 [-0.9,0.5] |
-4.5 [-6.1,-1.9] € § |
€ < 0.001 |
|
LPS + TEA - |
-1.6 [-2.7,-0.5] |
-9.7 [-11.8,-7.2] € |
€ < 0.001 |
|
LPS + TEA + |
0.4 [-0.5,1.7] $ |
-6.8 [-8.7,-4.2] € § |
€ < 0.001 |
Leukocytes (103 μl-1) |
LPS - TEA - |
9.5 [8.4,11.8] |
18.5 [15.6,19.7] € |
€ < 0.001 |
|
LPS + TEA - |
12.0 [10.6,13.9] |
4.4 [3.4,5.9] € * |
€ < 0.001 |
|
LPS + TEA + |
9.2 [8.0,11.7] |
5.3 [3.3,6.6] € * |
€ < 0.001 |
Platelets (103 μl-1) |
LPS - TEA - |
995 [843,1109] |
867 [724,997] € |
€ 0.002 |
|
LPS + TEA - |
919 [827,1053] |
120 [97,204] € * |
€ < 0.001 |
|
LPS + TEA + |
941 [807,1030] |
165 [94,379] € * |
€ < 0.001 |
Sodium (mM) |
LPS - TEA - |
141 [139,143] |
141 [139,143] |
|
|
LPS + TEA - |
142 [141,143] |
142 [141,144] |
|
|
LPS + TEA + |
141 [140,142] |
141 [140,143] |
|
Potassium (mM) |
LPS - TEA - |
4.4 [4.3,4.7] |
4.0 [4.0,4.3] € |
€ 0.003 |
|
LPS + TEA - |
4.5 [4.3,4.8] |
4.6 [4.2,4.9] * |
|
LPS + TEA + | 4.4 [4.3,5.1] | 4.3 [4.1,4.5] |
LPS = lipopolysaccharide, paCO2 = arterial partial pressure of carbon dioxide, paO2 = arterial partial pressure of oxygen, TEA = thoracic epidural anesthesia.
Data are median [quartiles], € p-values as depicted in the table vs. baseline, *p < 0.05 vs. LPS - TEA -; $ p < 0.05 vs. LPS + TEA -, § p < 0.05 versus LPS + TEA –.