Table 1.

Common antineoplastics tested in combination with heat.

Classification	Common name	Effect on cell cycle	Mode of action	Synergy with heat	Ref.
Platinum	Cisplatin Oxaliplatin Carboplatin	G1/S	Formation of DNA adducts	More than additive	[121]
Taxanes	Paclitaxel Docetaxel	G2/M	Microtubule stabilization	Complex (depends on cell type)	[121]
Campothecin	Irinotecan Topotecan	S/G2	Topoisomerase I inhibitor		[161]
Pyrimidine antagonists	5-fluorouracil Cytarabine (Ara C)	S	DNA inhibition	Independent	[81,115,118]
Dihydropyrimidine dehydrogenase inhibitor	Gimeracil	S	Inhibits DNA double-strand break repair		[162]
Nucleoside analogs	Gemcitabine	S	DNA inhibition		[132,133,163,144]
Alkylating agents	Cyclophosphamide Mephalan Ifosfamide Mitomycin C	G1/S	Incorporates an alkyl group to DNA guanine’s bases	More than additive	[81,118]
Vinca alcaloids	Vincristin Vinblastine	M	Mitotic inhibitor that prevents microtubule assembly	Independent	[121]
Proteasome inhibitors	Bortezomib	G2/M	Binds to 26S proteasome	More than additive	[126,127,164]
ROS-generating species	Tert-butyl hydroperoxide	S		More than additive	[165–167]
Heat shock protein Inhibitors	Geldanamycin Flavonoids Tanespimycin	Effect on G1 and G2 checkpoint proteins	Decrease in the amount of checkpoint proteins produced	More than additive	[129,134–136]
PARP-1 inhibitors	NU1025 PJ-34	S	Repair inhibition of single-strand breaks		[168]
Antibiotics	Bleomycin Doxorubicin Actinomycin D		Breaks DNA DNA intercalation DNA transcription inhibitor	Complex	[81,118]

ROS: Reactive oxygen species.