Table 2.
Association of parental longevity and cross-sectional and longitudinal measures of cognition in adult offspring
| Cross-sectional (n = 728) |
Longitudinal, annualised changeb (n = 557) |
|||
|---|---|---|---|---|
| Test | Beta estimate ± SE | P-value | Beta estimate ± SE | P-value |
| Logical memory delayed | 0.01 ± 0.07 | Ns | −0.03 ± 0.08 | Ns |
| Visual reproduction delayed | 0.07 ± 0.07 | Ns | 0.18 ± 0.08 | 0.023 |
| Paired associates delayed | 0.09 ± 0.07 | Ns | −0.12 ± 0.08 | Ns |
| Trail Making Test Aa | −0.21 ± 0.08 | 0.006 | −0.18 ± 0.08 | 0.038 |
| Trail Making: Test B-Test Aa | 0.05 ± 0.07 | Ns | −0.19 ± 0.09 | 0.031 |
| Similarities Test | 0.11 ± 0.07 | Ns | −0.03 ± 0.08 | Ns |
| HVOTa | 0.14 ± 0.07 | Ns | 0.05 ± 0.09 | Ns |
| BNTa | 0.06 ± 0.07 | Ns | 0.08 ± 0.09 | Ns |
The bold values are statistically significant.
Model: adjusted for age, sex, education, time to NP assessment; longitudinal change analysis additionally adjusted for baseline value of the test. Beta estimates (adjusted differences in means) and standard errors are presented to report the magnitude of effect of parental longevity on cognitive test performance in adult offspring.
ns, not significant (P > 0.05).
aNatural log-transformed.
bMean follow-up time 6.7 ± 1.7 years, range 1–11 years; annualised change in NP test measures was calculated as the difference between the last and first measurement divided by the time interval between the two measurements.