Table 3.
Association of parental longevity and cross-sectional and longitudinal brain MRI measures in adult offspring
| Cross-sectional (n = 639) |
Longitudinal: annualised changeb (n = 450) |
|||
|---|---|---|---|---|
| Beta estimate ± SE or odds ratio (95% CI) | P-value | Beta estimate ± SE | P-value | |
| TCBV | 0.02 ± 0.07 | ns | 0.13 ± 0.11 | ns |
| Hippocampal volume | −0.03 ± 0.08 | ns | N/A | ns |
| Frontal lobe volume | −0.05 ± 0.07 | ns | 0.01 ± 0.09 | ns |
| Temporal lobe volume | −0.01 ± 0.08 | ns | −0.05 ± 0.09 | ns |
| Temporal horn volumea | −0.05 ± 0.07 | ns | −0.25 ± 0.09 | 0.005 |
| WMHV† | −0.11 ± 0.07 | ns | −0.09 ± 0.08 | ns |
| Large-WMHV | 0.59 (0.38, 0.92) | 0.019 | N/A | |
| SCI | 0.87 (0.55, 1.38) | ns | N/A | |
The bold values are statistically significant.
Model: adjusted for age, sex, time to brain MRI; longitudinal analysis additionally adjusted for baseline value. Beta estimates (adjusted differences in means) and standard errors or odds ratios and 95% confidence intervals are presented to report the magnitude of effect of parental longevity on brain MRI volumes in adult offspring.
N/A, not available; ns, not significant (P > 0.05).
aNatural log-transformed.
bMean follow-up time 6.7 ± 1.7 years; annualised change in brain MRI volumes was calculated as the difference between the last and first measurement divided by the time interval between the two measurements.