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. 2014 Apr 24;5(4):e1189. doi: 10.1038/cddis.2014.140

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Hearing impairment in APN-KO mice has an early onset and a progressive course. ABR hearing thresholds were measured at 8, 16, and 32 kHz, in WT and APN-KO mice at 2 months and 6 months of age (n=5–7). At 2 months and at 6 months of age, WT mice did not show any threshold shifts at any frequencies. At 2 months of age, APN-KO mice exhibited a slight increase in ABR thresholds at high frequency (32 kHz) as compared with WT mice (*P<0.01). At 6 months of age, APN-KO mice showed significantly increased (**P<0.01) ABR thresholds at 8, 16, and 32 kHz, as compared with WT mice at the ages of both 2 months and 6 months, and with APN-KO mice at the age of 2 months. This change in APN-KO mice at the age of 6 months was greatest at the high frequency tested (32 kHz)