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. 2014 Apr 24;5(4):e1189. doi: 10.1038/cddis.2014.140

Figure 4.

Figure 4

APN supplementation prevents hearing impairment in APN-KO mice. (a) Supplementation with APN could rescue the hearing impairment that was seen in Ad-β-gal-treated APN-KO mice (n=4, *P<0.01). At the age of 2 months, Ad-β-gal-treated APN-KO mice exhibited an increase in ABR thresholds at 32 kHz as compared with Ad-β-gal-treated WT mice of the same age (n=4, **P<0.05). (b) Supplementation of APN in APN-KO mice increased CBF. Quantitative analyses of CBF ratio are shown (n=4 per group). (c) Ad-APN in APN-KO mice increased the capillary density of the SV. Quantitative analyses of the capillary density in the SV are shown (n=4 per group). (d) Ad-APN in APN-KO mice decreased the frequency of TUNEL-positive cells in the organ of Corti. Representative photographs of TUNEL-positive (green) nuclei in the organ of Corti are shown (n=4 per group)