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. 2014 Apr 17;5(4):e1181. doi: 10.1038/cddis.2014.145

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Caspase-14 and mesotrypsin were hardly detectable in parakeratotic skin areas. (a) Localizations of caspase-14 (C14) and mesotrypsin in normal (left) and psoriatic skin (right three panels). Representative images from three different patients are shown. (b) Localizations of caspase-14 and mesotrypsin in skin with AD. Top indicates localization of mesotrypsin, middle indicates localization of caspase-14 and bottom indicates merged images with nuclear staining (DAPI). (c) ICAD immunostaining and nuclear staining on the skin surface of a subject with AD. A high-magnification picture is also shown. Note the colocalization of ICAD and nuclei. Scale bar: 200 μm