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. 2014 Apr 17;5(4):e1178. doi: 10.1038/cddis.2014.159

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Suppression of lung metastasis of 4T1_PB3R cells in female Balb/c mice by GC-HIFU treatment. (a) Schematics of GC-HIFU treatment. (b) Progression of 4T1_PB3R tumors in mice under different treatments, determined by IVIS imaging system (N=6 for each experimental group). (c) Bioluminescent signals from non-primary tumor sites among different experimental groups, in comparison with that of untreated control group, according to the IVIS data. *P<0.05. (d) Tumor metastasis in lung sections detected using hematoxylin and eosin staining (marked with asterisks). The scale bar of each picture is 200 μm