Figure 1.
Typical two-color I-FISH results are depicted for three interphase nuclei of the melanoma patients. A) Two signals each in red and green were interpreted as a normal result, indicating the presence of two PROBABLY intact chromosomes 22. B) Loss of one red signal was interpreted as interstitial or terminal loss of chromosome 22q including the NF2 gene region. C) Loss of one red and one green signal were interpreted as mono-somy 22. D) Schematic depiction of the probes and their localization on chromosome 22 (#22).