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. 2014 Apr 17;124(5):2198–2203. doi: 10.1172/JCI61368

Figure 1. AT1A receptor deficiency on macrophages exacerbates kidney fibrosis induced by UUO.

Figure 1

(A) Representative kidney sections from LysM-Cre+ mT/mG mice 7 days after UUO with contralateral unobstructed kidney on left and obstructed kidney on right. (B) Polarized images of representative sections from obstructed WT and Macro KO kidneys stained with picrosirius red for collagen fibrils at day 7 after UUO. Original magnification, ×20. (C) Western blot for Col I in whole kidney at day 7 after UUO. (D) mRNA expression of ColI, Pai1, and Tgfb1 in obstructed kidney at day 7 after UUO. (E) Gene expression of M1 markers Il1b, Il1r1, Tnfa, Il12b, and Ccl2 and M2 markers Arg1, Fizz1, Ym1, and Il1r2 in obstructed kidneys at 3 and 7 days after UUO. At day 3, *P < 0.02 vs. WT, †P = 0.02 vs. WT, ‡P = 0.01 vs. WT, #P = 0.03, §P < 0.02. At day 7, *P < 0.03 vs. WT, †P = 0.02 vs. WT, #P = 0.05, §P < 0.001.