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. 2014 Apr 1;124(5):1987–1999. doi: 10.1172/JCI70324

Figure 1. Abnormal serum TH and TSH concentrations in Mct8/Oatp1c1 DKO mice.

Figure 1

Serum samples of 8 animals per genotype were analyzed at P21 and revealed increased T3 and decreased T4 serum levels in Mct8/Oatp1c1 DKO mice (M/O DKO) as well as in Mct8 KO mice, whereas Oatp1c1 KO mice did not exhibit any alterations in serum TH parameters. Serum TSH concentrations were elevated in Mct8 KO mice and even more so in Mct8/Oatp1c1 DKO animals, which suggests that in the absence of both TH transporters, the HPT abnormalities characteristic of Mct8 deficiency are even more pronounced. *P < 0.05, **P < 0.01, ***P < 0.001 vs. WT, or as otherwise indicated (brackets).