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. 2014 Apr 1;124(5):1987–1999. doi: 10.1172/JCI70324

Figure 4. Effect of combined MCT8 and OATP1C1 deficiency on TH metabolism in the CNS.

Figure 4

(A) Activities of the TH activating enzyme D2, separately measured in forebrain and cerebellar homogenates of animals at P21 (n = 6 per genotype), revealed a more than 10-fold elevation in Mct8/Oatp1c1 DKO mice, similar to that in athyroid Pax8 KO mice. (B) Determination of D3 enzymatic activities unveiled a similar reduction in Mct8 KO, Pax8 KO, and Mct8/Oatp1c1 DKO animals, whereas D3 activities were not significantly altered in Oatp1c1 KO animals. **P < 0.01, ***P < 0.001 vs. WT, or as otherwise indicated (brackets).