Figure 6. FTY720 induced activation of S1P1 in endothelial cells and hepatocytes.

FTY720 (1 mg/kg) or vehicle (ethanol/PBS, 1:1) was intraperitoneally injected into S1P1 GFP signaling mice, and the tissues were harvested 1 day after injection. Histological sections were immunostained with antibodies to CD31, LYVE-1, or albumin, and the images were captured using an inverted laser-scanning confocal microscope. The tissues of 3 mice for each treatment were examined. Scale bars: 50 μm.