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Proposed model of VEGF during liver fibrosis resolution. During fibrosis resolution, VEGF promotes monocyte infiltration and SAM accumulation in scar tissue by increasing sinusoidal endothelial cell permeability and stimulating monocyte migration. SAM in turn up-regulates CXCL9 expression. CXCL9 promotes Kupffer and activated stellate cells to produce MMP13 to remodel scar and promote fibrosis resolution.
