Table 1.

Risk for Stroke among Current Postmenopausal Hormone Users Compared to Women Who Never Used Hormones

	Cases	Person-Years	Age-adjusted Relative Risk (95% confidence interval)	Multivariate adjusted Relative Risk*
			Relative Risk
Total Stroke
Never Used Hormones	360	485,987	1.0 (reference)
Current Use of:
Estrogen Alone	276	256,437	1.33 (1.13,1.55)	1.39 (1.18,1.63)
Estrogen + Progestin	138	153,192	1.17 (0.96,1.42)	1.27 (1.04,1.56)
Ischemic Stroke
Never Used Hormones	235	485,987	1.0 (reference)
Current Use of:
Estrogen Alone	183	256,437	1.33 (1.09,1.61)	1.43 (1.17,1.74)
Estrogen + Progestin	103	153,192	1.32 (1.05,1.67)	1.53 (1.21,1.95)
Hemorrhagic Stroke
Never Used Hormones	85	485,987	1.0 (reference)
Current Use of:
Estrogen Alone	61	256,437	1.35 (0.97,1.88)	1.37 (0.98,1.91)
Estrogen + Progestin	24	153,192	0.88 (0.56,1.38)	0.87 (0.55,1.39)
Fatal Stroke
Never Used Hormones	50	485,987	1.0 (reference)
Current Use of:
Estrogen Alone	33	256,437	1.20 (0.77,1.86)	1.22 (0.78,1.90)
Estrogen + Progestin	15	153,192	0.93 (0.52,1.66)	1.03 (0.57,1.86)
Non-fatal Stroke
Never Used Hormones	310	485,987	1.0 (reference)
Current Use of:
Estrogen Alone	243	256,437	1.35 (1.14,1.60)	1.41 (1.19,1.68)
Estrogen + Progestin	123	153,192	1.20 (0.98,1.48)	1.31 (1.05,1.62)

^*Adjusted for age, BMI, high cholesterol, diabetes, high blood pressure, husband’s education, smoking, family history premature MI.