Table 1.
Good responders (N=40) | Poor responders (N=36) | p-value | |
---|---|---|---|
Demographics | |||
Gender* (%Men [N]) | 50% [20] | 47% [17] | 0.81 |
Age (year) | 44.0±14.4 | 42.8±12.2 | 0.69 |
BMI (kg/m2) | 26.5±4.4 | 26.2±4.3 | 0.78 |
Platelet aggregation, collagen 2 μg/mL | |||
Before aspirin (Ω) | 13.3±1.9 | 14.2±1.9 | 0.05 |
After aspirin (Ω) | 5.7±1.9 | 14.2±1.9 | <0.0001 |
Change* (Ω) | -7.6 ±2.1 | 0.03±2.3 | <0.0001 |
Platelet aggregation, arachidonic acid | |||
Before aspirin (Ω) | 9.4±2.8 | 11.0±3.0 | 0.02 |
After aspirin (Ω) | 0.4±1.3 | 2.0±3.5 | 0.01 |
Change (Ω) | -9.0 ±3.2 | -9.1±4.4 | 0.97 |
Samples were categorized as good and poor responders based on change in collagen stimulated ex vivo platelet aggregation and selected to have approximately equal numbers of men and women in each category.