Table 2.

Changes in Individual Metabolite Levels Post-Aspirin

Metabolite	HMDB ID	Before Aspirin	After Aspirin	Change	P-value
Salicylic acid	HMDB01895	0.1±0.4	1.8±0.8	↑	<1×10-3
Salicyluric acid	HMDB00840	0.5±0.2	1.4±0.9	↑	<1×10-3
Azelaic acid	HMDB00784	1.3±0.9	0.6±0.4	↓	<1×10-3
D-Ribose	HMDB00283	1.3±1.1	0.6±0.7	↓	<1×10-3
L-Aspartic acid	HMDB00191	1.2±0.3	0.7±0.2	↓	<1×10-3
Inosine*	HMDB00195	0.7±0.7	1.2±0.8	↑	<1×10-3
Guanosine*	HMDB00133	0.7±0.5	1.2±0.7	↑	<1×10-3
Adenosine-5-monophosphate*	HMDB00045	0.8±0.2	1.1±0.6	↑	<1×10-3
Oleic acid	HMDB00207	1.1±0.5	0.8±0.6	↓	<1×10-3
Palmitoleic acid	HMDB03229	1.1±0.7	0.8±0.8	↓	<1×10-3
Linoleic acid	HMDB00673	1.1±0.4	0.8±0.6	↓	<1×10-3
Hypoxanthine*	HMDB00157	1.1±0.6	0.8±0.5	↓	<1×10-3
Shikimic acid	HMDB03070	1.1±0.4	0.8±0.3	↓	<1×10-3
Xanthine*	HMDB00292	1.1±0.4	0.8±0.4	↓	<1×10-3
Arachidonic acid	HMDB01043	1±0.3	0.9±0.4	↓	0.002
3-Phosphoglyceric acid	HMDB00807	1.1±0.4	0.8±0.2	↓	0.003
Adenosine*	HMDB00050	0.8±0.7	1.1±0.9	↑	0.004
2,5-Furandicarboxylic acid	HMDB04812	0.9±0.4	1±0.5	↑	0.008

Data represent standardized mean ± SD of metabolite levels for all individuals (N=76), divided by mean metabolite level detected in this study. P-values calculated using LMM. Only metabolites with p<0.05 and q<0.1 are displayed.

^*Indicates member of Purine Metabolism pathway.