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Effect of electrical stimulus-mitochondrial energetics lag time (ES-MElag) on reentry induced by the metabolic sink. (A) ΔΨm distribution at the time when S1 reaches the edge of the metabolic sink as ES-MElag is varied. (B) Dynamics of ΔΨm recovery at the metabolic sink center with different lag times. (C) Recovery of ΔΨm induces rebound propagation or fibrillation depending on ES-MElag. (D) Summary of the effect of lag times on the induction of arrhythmias. σKATP=3.8/μm2, r=2cm.
