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. 2014 Mar 5;592(Pt 8):1839–1856. doi: 10.1113/jphysiol.2013.268706

Figure 5. Effect of MK801 on the HVR in CON and CSH rats.

Figure 5

Effects of chronic hypoxia and an NMDAR antagonist (MK801) on (A) VI, (C) fR and (E) VT in CON and CSH rats before and after microinjection of MK801. Effect of chronic hypoxia and MK801 on the magnitude of the HVR of (B) VI, (D) fR and (F) VT. Data are means ± s.e.m. from n = 13 CON and 8 CSH rats. *Significant difference between CON and CSH values. †Significant difference between artificial cerebral spinal fluid and drug injections. ‡No significant difference between 10% and 21% O2 (P < 0.05). CON, controls; CSH, chronic sustained hypoxia; fR, breathing frequency; HVR, hypoxic ventilatory response; VI, total minute ventilation; VT, tidal volume.