Figure 8. Effect of chronic hypoxia and/or NBQX on ventilation in CON and CSH rats.

Effects of chronic hypoxia and an AMPA receptor antagonist (NBQX) on (A) T_I, (B) T_E and (C) V_T/T_I for CON and CSH rats before and after microinjection of NBQX. Data are means ± s.e.m. from n = 13 CON and 11 CSH rats. *Significant difference between CON and CSH values. †Significant difference between artificial cerebral spinal fluid and drug injections. ‡No significant difference between 10% and 21% O₂ (P < 0.05). CON, controls; CSH, chronic sustained hypoxia; T_E, expiratory time; T_I, inspiratory time; V_T/T_I, ventilatory drive to breathe.