Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb;143(2):269–287. doi: 10.1085/jgp.201311089

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Csanády and Töröcsik

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 10. — Dose dependence of NPPB gating effects. Macroscopic closing rates of WT (closed circles) and K1250A (closed squares) CFTR in the presence of various cytosolic [NPPB], measured at −120 mV using the protocols shown in Figs. 3 A and 4 A, respectively; leftmost data points represent control values in the absence of NPPB. The 50- and 100-µM data points for K1250A were measured at −40 mV. Solid lines are fits to the equation r_OC([NPPB]) = r₀ + (r_∞ − r₀)([NPPB]/([NPPB] + K_1/2)), with r_∞ fixed to zero for WT but left free for K1250A; K_1/2 values are plotted. Open diamonds and dotted line depict fractional pore block at −120 mV, replotted from Fig. 1 J.