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. 2014 Feb;143(2):269–287. doi: 10.1085/jgp.201311089

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© 2014 Csanády and Töröcsik

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Figure 2. — Discrepancy between macroscopic and unitary effects on WT CFTR quantifies gating stimulation. (A and C) Dose-dependent inhibition by cytosolic NPPB (A) and MOPS⁻ (C) of steady-state macroscopic WT CFTR currents in 2 mM ATP at −120 mV. (B and D) Dose dependence of fractional currents in (B) NPPB and (D) MOPS⁻ at −120 mV (closed symbols), and Hill fits (solid lines); open symbols and dotted lines show dose dependence of pore block, replotted from Fig. 1 (J and L). (E) Gating stimulation by NPPB and MOPS⁻ at −120 mV; P_o/P_{o; control} was calculated as the ratio (I/I_control):(i/i_control).