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. 2014 Feb;143(2):269–287. doi: 10.1085/jgp.201311089

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© 2014 Csanády and Töröcsik

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Figure 7. — Stimulation of ΔF508 CFTR gating by NPPB. (A and B) Quasi-macroscopic currents of low temperature–rescued, prephosphorylated ΔF508 CFTR channels in 2 mM ATP at −120 mV (A) and +60 mV (B), and brief exposures to 210 µM NPPB. Note overall current stimulation by NPPB, and extreme current overshoot upon its removal, at −120 mV. (C and D) Fractional effects of 210 µM NPPB on (C) steady-state macroscopic currents and (D) P_o of ΔF508 CFTR at −120 mV (yellow bars) and +60 mV (cyan bars).