Skip to main content
. Author manuscript; available in PMC: 2014 Apr 28.
Published in final edited form as: Biochem Pharmacol. 2011 May 25;82(3):201–209. doi: 10.1016/j.bcp.2011.05.015

Figure 2. Mutated BRAF drives the invasion of melanoma cells.

Figure 2

Mutant BRAF regulates melanoma cell invasion through MEK/ERK-mediated signaling to RND3 and Rho/ROCK/LIM-mediated Cofilin phosphorylation. It is also known that ERK can upregulate BRN2 expression leading to the downregulation of PDE5A and cytoplasmic accumulation of cGMP and Ca2+. Increased intracellular calcium in turn leads to increased MLC2 phosphorylation, contractility, and invasion.