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Magnetic resonance images from the proband of family 1. Sagittal T1-weighted (A), axial T2-weighted (B), and coronal T1-weighted (C) images show marked thinning of the corpus callosum; diffuse confluent white matter abnormalities in the periventricular white matter, especially adjacent to the anterior and posterior horns of the lateral ventricle; cortical atrophy; and disproportionally enlarged ventricles.
