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. Author manuscript; available in PMC: 2014 Jul 16.
Published in final edited form as: Nature. 2013 Dec 8;505(7483):412–416. doi: 10.1038/nature12807

Figure. 1. Muc5b is required for survival and particle clearance.

Figure. 1

a-d, Muc5b+/+, Muc5b−/−, and Muc5ac−/− olfactory glands (a), nasopharynxes (b), tracheal glands (c), and bronchial surface epithelial cells (d) stained with AB-PAS or with anti-Muc5b (c,d bottom). Solid arrowheads, mucous cells. Open arrowheads, ciliated cells. e-i, Effects of mucin expression on growth, survival, MCC, and ciliary function. j-l, Microsphere movement, transport velocity, and transport index in primary tracheal epithelial cells in vitro. Scale bars, 20 μm (a, j), 10 μm (b-d). Error bars, sem. ‘*’ significant differences (p<0.05). Numbers in parentheses, ‘n’ mice.