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L655,240 inhibits Aβ40, Aβ42, and sAPPβ production in HEK293-APPswe cells. (A–C) L655,240 inhibited Aβ40, Aβ42, and sAPPβ secretion in media in a dose-dependent manner. (D–E) L655,240 reduced the levels of Aβ40 and sAPPβ in cell lysates. (F) L655,240 had no effect on cell viability as measured by MTT assay in HEK293-APPswe cells. Data are presented as the mean±SEM of three independent experiments. aP>0.05, bP<0.05, cP<0.01 vs DMSO group.
