TABLE 1.
Baseline Characteristics of Study Cohort
| Characteristics | Cases (N=681) |
Non-cases (N=65,531) |
Age- and sex-adjusted HR (95% CI) |
|---|---|---|---|
| Age, N (%) | N/A | ||
| 50 to <55 years | 64 (9.4) | 16,441 (25.1) | |
| 55 to <60 years | 128 (18.8) | 15,511 (23.7) | |
| 60 to <65 years | 116 (17.0) | 11,925 (18.2) | |
| 65 to <70 years | 144 (21.2) | 10,314 (15.7) | |
| ≥70 | 229 (33.6) | 11,340 (17.3) | |
| Gender, N (%) | |||
| Female | 272 (40.0) | 33,361 (50.9) | 1.00 (Reference) |
| Male | 409 (60.0) | 32,170 (49.1) | 1.65 (1.41–1.92), P<0.001 |
| Race/Ethnicity, N (%) | |||
| White | 631 (92.7) | 59,948 (91.5) | 1.00 (Reference) |
| Hispanic | 9 (1.3) | 576 (0.9) | 1.73 (0.89–3.35), P=0.103 |
| Other | 32 (4.7) | 3,910 (6.0) | 0.81 (0.57–1.16), P=0.249 |
| Missing Information | 9 (1.3) | 1,097 (1.7) | |
| Education, N (%) | |||
| High school graduate or less | 150 (22.0) | 12,504 (19.1) | 1.00 (Reference) |
| Some college | 233 (34.2) | 24,674 (37.7) | 0.93 (0.76–1.14), P=0.495 |
| College or advanced degree | 289 (42.4) | 27,276 (41.6) | 1.02 (0.84–1.25), P=0.813 |
| Missing Information | 9 (1.3) | 1,077 (1.6) | |
| Smoking Status (Cigarettes) | |||
| No, N (%) | 307 (45.1) | 31,329 (47.8) | 1.00 (Reference) |
| Yes, N (%) | 367 (53.9) | 33,775 (51.5) | |
| Pack-years, mean (SD)* | 27.5 (23.6) | 25.7 (23.2) | 1.00 (1.00–1.00), P=0.917 |
| Missing Information, N (%) | 7 (1.0) | 427 (0.7) | |
| Family History of Leukemia/Lymphoma, N (%) | |||
| None | 615 (90.3) | 61,239 (93.5) | 1.00 (Reference) |
| 1 first degree relative | 42 (6.2) | 3,338 (5.1) | 1.23 (0.90–1.68), P=0.188 |
| ≥2 first degree relatives | 6 (0.9) | 147 (0.2) | 3.65 (1.63–8.20), P=0.002 |
| Missing Information | 18 (2.6) | 807 (1.2) | |
| Vegetable Intake (servings/day), N (%) | |||
| 1st tertile (<1.25) | 213 (31.2) | 19,874 (30.3) | 1.00 (Reference) |
| 2nd tertile (1.25–2.16) | 219 (32.1) | 19,867 (30.3) | 1.02 (0.84–1.23), P=0.875 |
| 3rd tertile (>2.16) | 194 (28.5) | 19,954 (30.5) | 0.96 (0.79–1.17), P=0.683 |
| Missing Information | 55 (8.1) | 5,836 (8.9) | |
| Fruit Intake (servings/day), N (%) | |||
| 1st tertile (<0.93) | 218 (32.0) | 19,868 (30.3) | 1.00 (Reference) |
| 2nd tertile (0.93–1.94) | 190 (27.9) | 19,969 (30.4) | 0.84 (0.69–1.01), P=0.070 |
| 3rd tertile (>1.94) | 218 (32.0) | 19,931 (30.4) | 1.01 (0.83–1.22), P=0.957 |
| Missing Information | 55 (8.1) | 5,836 (8.9) | |
| Self-Reported Health, N (%) | |||
| Excellent | 78 (11.5) | 10,220 (15.6) | 1.00 (Reference) |
| Very Good | 255 (37.4) | 25,467 (38.9) | 1.24 (0.96–1.59), P=0.100 |
| Good | 241 (35.4) | 21,571 (32.9) | 1.34 (1.03–1.72), P=0.026 |
| Fair | 78 (11.5) | 6,242 (9.5) | 1.52 (1.11–2.08), P=0.009 |
| Poor | 15 (2.2) | 1,028 (1.6) | 2.09 (1.21–3.63), P=0.009 |
| Missing Information | 14 (2.1) | 1,003 (1.5) | |
| Physical Activity average in 10 years (MET hours/week), N (%) | |||
| None | 123 (18.1) | 9,550 (14.6) | 1.00 (Reference) |
| 1st quartile (≤3.0) | 124 (18.2) | 13,629(20.8) | 0.74 (0.58–0.95), P=0.018 |
| 2nd quartile (>3.0–8.1) | 138 (20.3) | 13,805 (21.1) | 0.77 (0.60–0.98), P=0.032 |
| 3rd quartile (>8.1–17.8 | 137 (20.1) | 13,744 (21.0) | 0.73 (0.57–0.93), P=0.012 |
| 4th quartile (>17.8) | 144 (21.2) | 13,916 (21.2) | 0.72 (0.56–0.91), P=0.007 |
| Missing Information | 15 (2.2) | 887 (1.4) |
*
Among smokers and former smokers.
Abbreviations: CI, confidence interval; HR, hazard ratio; N/A, not applicable; SD standard deviation