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. Author manuscript; available in PMC: 2014 Apr 28.
Published in final edited form as: Neurobiol Dis. 2012 Mar 9;46(3):692–700. doi: 10.1016/j.nbd.2012.03.010

Fig. 3.

Fig. 3

MS analysis reveals the presence of QA and DiOH-CBZ. (A–A1) Fraction 1 was collected by HPLC and analyzed by MS. We found m/z=167.96 and 168.0 in positive ion mode matching the molecular weight of quinolinic acid (QA, see also Table 2). A protonated form of kynurenine (a precursor of QA, m/z=209.03) was also detected in this fraction (see Table 2). (B) Fraction 4 contained 10, 11-dihydro-10, 11-dihydroxy-carbamazepine (DiOH-CBZ, m/z=270.98 m/z M+H+) and for molecular ion identification see Table 2. Known CBZ metabolites were identified in the remaining fractions (see Supplementary Fig. 1).