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. Author manuscript; available in PMC: 2014 Apr 28.
Published in final edited form as: Neurobiol Dis. 2012 Mar 9;46(3):692–700. doi: 10.1016/j.nbd.2012.03.010

Fig. 4.

Fig. 4

HPLC-UV determination of quinolinic acid (QA). (A–B) The presence of QA in fraction 1 was confirmed using two ad hoc HPLC-UV methods. (A1–B1) Levels of QA are significantly higher in the brain compared to serum. Brain levels detected using the two methods were identical (8.09 μM and 7.56 μM); note that the elution time of standards matched chromatograms of brain or serum samples (2.9 and 6.8 min in A and B respectively). (A2–B2) Dose response of QA was performed using two HPLC methods (* indicates p<0.05, data are presented as mean±SEM).