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. Author manuscript; available in PMC: 2015 Mar 10.
Published in final edited form as: Brain Res. 2013 Dec 31;1551:25–44. doi: 10.1016/j.brainres.2013.12.029

Figure 16. Oral delivery of tropisetron is as effective as pump delivery for improving working memory.

Figure 16

(A) J20 mice receiving either vehicle or tropisetron by pump were still hyperactive as compared to NTg mice (P = 0.0004 and P = 0.0303, respectively), but hyperactivity was reversed by tropisetron orally (P = 0.0461; not significantly different than control NTg). (B) Compared to NTg mice, vehicle-treated J20s had significantly (P = 0.0409) lower novelty preference (NP). There was no significant difference in NP between NTg and either tropisetron-treated group, but only mice treated with tropisetron by pump had significantly (P = 0.0075) greater NP than vehicle-treated J20s.