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. Author manuscript; available in PMC: 2015 Mar 10.
Published in final edited form as: Brain Res. 2013 Dec 31;1551:25–44. doi: 10.1016/j.brainres.2013.12.029

Figure 7. Meta-analysis of tropisetron effects on sAPPα and Aβ1–42 in hippocampus/entorhinal cortex.

Figure 7

(A) When sAPPα values for individuals from eight separate in vivo experiments (vehicle n = 68, tropisetron n = 67) are converted to percentage of vehicle control for those experiments, the increase in sAPPα as a result of tropisetron treatment is very highly significant (P = 0.0001). (B) Decreases in Aβ1-42 are also highly significant (P = 0.0021). The sAPPα/Aβ1-42 is also highly significant (0.0008) (Fig. 7C). All t-test, two-tailed, unpaired statistical analyses.