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. Author manuscript; available in PMC: 2015 Mar 10.
Published in final edited form as: Brain Res. 2013 Dec 31;1551:25–44. doi: 10.1016/j.brainres.2013.12.029

Figure 8. Tropisetron-treated mice show improvements in spatial memory.

Figure 8

Mice were treated for 8 weeks as described in Methods. In the last 2 weeks of treatment, mice performed the Morris Water Maze (MWM) spatial memory task. (A) In training, J20 mice treated with tropisetron found the hidden platform significantly faster than vehicle treated J20s by Day 5 of training (P = 0.0113), but did not become significantly faster with days of training. In the hidden probe, where the platform was removed and attempts of the mice to find it were recorded, while tropisetron-treated J20s spent more time in the platform quadrant (B) than vehicle-treated J20s, and crossed the platform site (C) more frequently, these increases were not significant; and while tropisetron-treated J20s crossed the platform significantly fewer times than NTg (P = 0.0196), vehicle-treated mice crossed far less (P = 0.0005). (D) Tropisetron-treated J20s’ latency to the platform site was significantly improved over vehicle-treated J20 (P < 0.05) and not significantly different than NTg; vehicle-treated J20s were much slower (P = 0.0002) than NTgs (ANOVA, Bonferroni post-hoc). (E) All mice floated rather than initially swimming actively at first, with vehicle-treated J20s floating the most, significantly more than the NTgs (P = 0.0088); tropisetron-treated mice were intermediate.