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. Author manuscript; available in PMC: 2015 Apr 8.
Published in final edited form as: Structure. 2014 Feb 20;22(4):602–611. doi: 10.1016/j.str.2014.01.008

Figure 3. NO-induced conformational changes of the full-length sGC heterodimer.

Figure 3

Changes in HD exchange kinetics induced by NO-binding in full length α1β1 sGC with noncyclizable GTP analog GPCPP. Peptide coverage from HDX-MS analysis is represented by bars overlaying primary sequence of α1 (left) and β1 (right) sGC. Peptides exhibiting significant NO-induced exchange rate changes are color-coded according to the scale bar. Peptides exchanging more rapidly upon NO-binding are colored in red hues, whereas peptides exchanging more slowly are in blue hues. Asterisks denote the results of two-tailed, unpaired Student’s t-tests. Peptides exhibiting non-significant or undetectable changes are colored gray.