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Permeability parameters with advancing age. The permeability index (= % lactulose/% mannitol) and the fractional urinary recovery of lactulose and mannitol are depicted with advancing age along with regression lines. Both lactulose and mannitol but not the permeability index trended to decrease with increasing age. Mildly impaired kidney function (glomerular filtration rate ≤ 60 mL/min) did not consistently lead to low recovery of test sugars as depicted by the black dots.
