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. 2011 Mar 28;32(4):487–494. doi: 10.1038/aps.2010.227

Figure 3.

Figure 3

(A and D) Effects of L-733060 (L, 10-6 mol/L), tetrodotoxin (TTX, 10-6 mol/L), and hexamethonium (Hex, 10-4 mol/L) on contractions caused by the agonist of tachykinin NK1, [Sar9] SP (Sar9, 100 nmol/L), in longitudinal and circular smooth muscle from rabbit duodenum, jejunum, and ileum. (B and E) Effects of GR-94800 (GR, 100 nmol/L), TTX, and Hex on contractions caused by the agonist of tachykinin NK2, (β-Ala 8)-NKA (β-NKA, 100 nmol/L), in longitudinal and circular smooth muscle from rabbit duodenum, jejunum, and ileum. (C and F) Effects of SB 218795 (SB, 100 nmol/L), TTX, and Hex on contractions caused by the agonist of tachykinin NK3, Senktide (Sk, 100 nmol/L), in longitudinal and circular smooth muscle from rabbit duodenum, jejunum, and ileum. Columns indicate the mean values of integrated mechanical activity (% of TK agonist), and vertical bars indicate SEM. bP<0.05, cP<0.01. Numbers in brackets indicate the number of segments.