Table 1. Effects of different doses of substance P (SP). Average values of the motor response (mN·s−1·mm−2) to SP of the longitudinal and circular muscle of the duodenum, jejunum and ileum of rabbits. In brackets it expresses in number of segments.
|
Duodenum |
Jejunum |
Ileum |
|||
---|---|---|---|---|---|---|
L | C | L | C | L | C | |
SP 1 nmol/L | 0.0±0.0 (8) | 0.0±0.0 (13) | 0.0±0.0 (10) | 0.0±0.0 (11) | 0.1±0.0 (9) | 0.1±0.0 (11) |
SP 10 nmol/L | 0.0±0.0 (9) | 0.0±0.0 (13) | 0.0±0.0 (10) | 0.0±0.0 (11) | 0.0±0.0 (9) | 0.0±0.0 (11) |
SP 100 nmol/L | 0.2±0.0 (9) | 0.0±0.0 (13) | 0.3±0.1 (10) | 0.1±0.0 (11) | 0.4±0.1 (9) | 0.1±0.0 (11) |
SP 1 μmol/L | 0.1±0.0 (9) | 0.0±0.0 (13) | 0.2±0.1 (10) | 0.1±0.0 (11) | 0.4±0.1 (9) | 0.1±0.0 (11) |
SP 10 μmol/L | 0.1±0.0 (8) | 0.1±0.0 (12) | 0.5±0.0 (8) | 0.2±0.0 (10) | 0.5±0.1 (8) | 0.1±0.0 (10) |