Table 2. Comparison of the effects of [Sar9] SP (100 nmol/L), NKA (100 nmol/L), (β-Ala-8) NKA (100 nmol/L), NKB (100 nmol/L), and Senktide (100 nmol/L) with respect to SP (100 nmol/L, 100%), on contractions of longitudinal (L) and circular (C) smooth muscle of rabbit duodenum, jejunum, and ileum. Values of integrated mechanical activity (% of SP) are the mean±SEM. Numbers in brackets indicate number of segments. cP<0.01.
| |
Duodenum |
Jejunum |
Ileum |
|||
|---|---|---|---|---|---|---|
| L | C | L | C | L | C | |
| SP | 100 (11) | 100 (8) | 100 (8) | 100 (12) | 100 (11) | 100 (10) |
| [Sar9] SP | 103.1±15.2 (8) | 128.3±28.4 (8) | 134.5±29.6 (8) | 131.1±21.3(8) | 116.2±19.2 (12) | 144.1±20.7 (8) |
| NKA | 87.9±4.1 (10) | 89.5±8.5 (6) | 90.9±2.1 (9) | 96.0±2.3 (5) | 98.2±5.0 (9) | 97.2±3.9 (8) |
| (β-Ala-8)NKA | 15.8±2.3 (8)c | 22.4±6.4 (8)c | 39.5±7.4 (8)c | 17.2±6.4 (8)c | 32.8±5.2 (10)c | 24.7±8.4 (9)c |
| NKB | 69.1±4.5 (10)c | 79.4±12.5 (6) | 72.5±4.1 (9)c | 91.2±5.1 (5) | 73.7±4.8 (14)c | 80.2±6.4 (5) |
| Senktide | 26.1±3.4 (10)c | 36.3±17.8 (5) | 8.9±2.2 (8)c | 8.3±2.6 (5)c | 6.5±1.0 (9)c | 6.9±0.4 (5)c |