Table 3. Comparison of the effects of different tachykinin receptor antagonists with respect to Substance P. Effect of L-733060 (1 μmol/L), GR-94800 (100 nmol/L), and SB 218795 (1 μmol/L) on SP (100 nmol/L) contractions on longitudinal (L) and circular (C) smooth muscle of rabbit duodenum, jejunum, and ileum. Values of integrated mechanical activity (% of SP) are the mean±SEM. Numbers in brackets indicate number of segments. bP<0.05; cP<0.01.
| |
Duodenum |
Jejunum |
Ileum |
|||
|---|---|---|---|---|---|---|
| L | C | L | C | L | C | |
| SP | 100 (11) | 100 (8) | 100 (8) | 100 (12) | 100 (11) | 100 (10) |
| L-733060+SP | 73.7±3.2 (9)c | 77.7±2.3 (10)c | 70.1±3.4 (8)c | 77.6±6.3 (9)c | 74.5±7.7 (7)c | 96.5±1.1 (7) |
| GR-94800+SP | 74.6±5.5 (6)c | 75.9±5.2 (7)c | 92.5±3.6 (5)b | 86.7±6.2 (7) | 85.2±1.4 (5)c | 70.9±6.3 (6)c |
| SB 218795+SP | 70.9±6.1 (8)c | 79.7±9.1 (8)c | 61.5±11.4 (9)c | 81.9±1.5 (9)c | 71.7±12.5 (8)b | 70.7±14.8 (8) |