Skip to main content
. Author manuscript; available in PMC: 2015 Mar 19.
Published in final edited form as: Tetrahedron Lett. 2014 Feb 18;55(12):2003–2005. doi: 10.1016/j.tetlet.2014.02.016

Table 2.

Reaction of 2 with Amines

RR'NH Tosylmethylurea 4 % Yielda
n-BuNH2 4a R=H, R'= n-Bu 61
n-BuNH2 4b R=H, R'= t-Bu 55
pyrrolidine 4c R,R'= (CH2)4 21
aniline 4d R=H, R'= Ph 72
o-phenylenediamine 4e R=H, R'= (o-NH2Ph) 54
a

Conditions: THF, −78 °C, 0.5 h; then stirring 1 h at rt, followed by concentration and purification by trituration or flash column chromatography.