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Gut peptide hormones and regulatory signals are released along the length of the gastrointestinal tract. Both ghrelin and leptin are secreted from the stomach, whereas CCK and GIP are secreted from I cells and K cells, respectively, in the duodenum. It is debated whether L cells, which secrete GLP-1, GLP-2, OXN, and PYY, are located in the duodenum. More distally secreted in the intestine are CCK and GIP from the jejunum, and GLP-1, GLP-2, OXN, and PYY from the ileum.
