FIGURE 2.

Gut nutrient-sensing mechanisms and subsequent peptide hormone release in normal and DJB surgery settings. Nutrient influx in both the duodenum and the jejunum triggers hormonal release and downstream signaling to lower GP through a neuronal network. In the duodenum, these mechanisms are disrupted upon high fat feeding. DJB surgery results in the influx of nutrients and hormones, such as leptin, directly into the jejunum to suppress GP through downstream mechanisms. ACS, acyl-CoA synthetase; NTS, nucleus of the solitary tract; SGLT1, sodium glucose luminal transporter-1.